The Targus AEH102 Headphones offer a hassle-free setup, not requiring additional drivers upon initial use due the C-Media based chipset which simplifies the plug-and-play experience for users across various devices. However, compatibility issues might arise when connecting to certain smartphones or similar devices due to default settings that occasionally disable external audio devices. These devices, prioritizing their built-in speakers or specific audio output options, might automatically deactivate or hinder the use of external audio peripherals like the AEH102 headphones. Users may need to manually enable or adjust settings on their smartphones to allow external audio devices for seamless connectivity and optimal functionality with the Targus AEH102 Headphones.